What does AP-1 transcription factor do?
Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections. AP-1 controls a number of cellular processes including differentiation, proliferation, and apoptosis.
What is the role of Sp1?
Sp1 is a ubiquitous nuclear factor that plays a key role in maintaining basal transcription of ‘house-keeping’ genes. However, recent evidence points to a more important function for Sp1 in mediating ‘cross-talk’ between selected signaling cascades to regulate the target genes that respond to these pathways.
Is Sp1 a transcription factor?
Sp1 (specificity protein 1) is a well-known member of a family of transcription factors that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential biological processes and have been proven important in cell growth, differentiation, apoptosis and carcinogenesis.
What is the position of the Sp1 binding site?
Sp1 binds to the GC box motif at nucleotide positions −81/−69 of the β1,4GalT V promoter and play an essential role in promoter activity in cancer cells (Sato and Furukawa, 2004).
What is SP3 in biology?
Sp3 transcription factor, also known as SP3, refers to both a protein and the gene it is encoded by. This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes.
What is SP1 DNA?
SP1 belongs to the Sp/KLF family of transcription factors. The protein is 785 amino acids long, with a molecular weight of 81 kDa. The SP1 transcription factor contains a zinc finger protein motif, by which it binds directly to DNA and enhances gene transcription.
What is SP1 gene?
SP1 (Sp1 Transcription Factor) is a Protein Coding gene. Diseases associated with SP1 include Embryonal Carcinoma and Cerebrotendinous Xanthomatosis. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding.
Where is SP1 expressed?
We found that Sp1 protein was expressed predominantly in the nuclei of cells located in the mucous neck region, whereas Sp1 expression was not detected either in the cells located toward the gastric pit (foveolar differentiation) or cells of the glandular epithelium (glandular differentiation).