What causes splenic sequestration?
Splenic sequestration happens when a lot of sickled red blood cells become trapped in the spleen. The spleen can enlarge, get damaged, and not work as it should. When the spleen doesn’t work well, a person is more likely to have serious, life-threatening infections with certain types of bacteria.
What are the symptoms of splenic sequestration?
What are the symptoms of splenic sequestration?
- Irritability.
- Pain on the left side of the abdomen.
- Weakness.
- Fast heart rate.
- Big spleen.
- Unusual Sleepiness.
- Looks pale.
Can splenic sequestration cause fever?
Acute splenic sequestration crisis and related cytopenia may be an unusual complication of fever of unclear origin in a beta-thalassemic carrier of a Hemoglobin Valletta mutation and polymorphism in homozygosis of intervening sequence 2 at nucleotide 745.
How is splenic sequestration treatment?
Treatment of splenic sequestration involves conservative management with blood transfusions/exchange transfusions to reduce the number of sickled red blood cells, or splenectomy. Splenectomy, if full, will prevent further sequestration and if partial, may reduce the recurrence of acute splenic sequestration crises.
What is acute splenic sequestration?
Acute splenic sequestration is a sudden enlargement of the spleen that can be life-threatening. In sickle cell disease, acute splenic sequestration can happen at any age, but normally it occurs in infants and young children.
What is sequestration of red blood cells?
Splenic sequestration is a potentially life-threatening condition that’s most commonly seen as a complication of sickle cell disease (SCD). It happens mostly in children. The condition causes a child’s spleen to get bigger and lowers the amount of oxygen-carrying red blood cells in their body.
What is splenic sequestration?
Splenic sequestration is a problem with the spleen that can happen in people who have sickle cell disease. Splenic sequestration happens when a lot of sickled red blood cells become trapped in the spleen. The spleen can enlarge, get damaged, and not work as it should.
What is sequestration in the spleen?
Sickle cells can block the blood vessels leading out of the spleen. When this happens, blood stays in the spleen instead of flowing through it. This causes the spleen to get bigger, and the blood counts to fall. This is called a splenic sequestration (SPLEN ik seh ques TRAY shun) crisis, or simply “spleen crisis.”
What is meant by splenic sequestration?
How does spleen remove red blood cells?
It recognizes and removes old, malformed, or damaged red blood cells. When blood flows into your spleen, your spleen performs “quality control”; your red blood cells must pass through a maze of narrow passages. Healthy blood cells simply pass through the spleen and continue to circulate throughout your bloodstream.