How long does a midazolam injection last?
For many people, midazolam can work within five minutes if it’s injected intravenously. Effects last from one to six hours. Midazolam has an amnesia effect, which lasts anywhere from 20 minutes to an hour. Most of a dose of midazolam is eliminated via urine, although some are eliminated via feces as well.
What is midazolam half life?
Six single-dose pharmacokinetic studies involving healthy adults yield pharmacokinetic parameters for midazolam in the following ranges: volume of distribution (Vd), 1 to 3.1 L/kg; elimination half-life, 1.8 to 6.4 hours (mean approximately 3 hours); total clearance (Cl), 0.25 to 0.54 L/hr/kg.
What is the duration of midazolam?
The onset of action is about 2 minutes after the injection. Maximum effect is obtained in about 5 to 10 minutes. The IV injection of midazolam should be given slowly at a rate of approximately 1mg in 30 seconds.
Why is midazolam given at end of life?
Muscle spasm. Parenteral benzodiazepines, such as midazolam, can be used to relieve muscle spasm and spasticity in the last days of life (Table 3).
How long do side effects of midazolam last?
The general side effects of Versed, such as loss of memory, coordination problems, and drowsiness, can last from one to two days, so activities like driving or going to work will have to wait until you are feeling normal again.
How fast does midazolam work?
Midazolam can be given by mouth, intravenously, by injection into a muscle, by spraying into the nose, or through the cheek. When given intravenously, it typically begins working within five minutes; when injected into a muscle, it can take fifteen minutes to begin working. Effects last between one and six hours.
What is half life of a drug?
The half-life of a drug is the time it takes for the amount of a drug’s active substance in your body to reduce by half. This depends on how the body processes and gets rid of the drug. It can vary from a few hours to a few days, or sometimes weeks.
How much midazolam can I take in 24 hours?
Initially 10–20 mg/24 hours, adjusted according to response; usual dose 20–60 mg/24 hours.
How much Midazolam can I take in 24 hours?