How do you administer etoposide?
Etoposide is administered by slow intravenous infusion (usually over a 30 to 60 minute period) (see section 4.4).
What is etoposide FDA approved for?
Etoposide is approved to be used with other drugs to treat: Small cell lung cancer. It is used with other chemotherapy as first-line treatment. Testicular cancer.
What should I monitor with etoposide?
Testicular, bladder, prostate, lung, stomach, and uterine, cancers. Hodgkin’s and non-Hodgkin’s lymphoma, mycosis fungoides, Kaposi’s sarcoma, Wilm’s tumor, rhabdomyosarcoma, Ewing’s sarcoma, neuroblastoma, brain tumors.
What is the difference between etoposide and etoposide phosphate?
Etopophos (etoposide phosphate) can be given in a smaller amount of fluid and over a faster period of time compared to another form of the medicine (etoposide) since Etopophos (etoposide phosphate) is not associated with a large drop in blood pressure during injection.
Does etoposide need a central line?
If you don’t have a central line Or you can have etoposide as capsules (Vepesid). You take these with a glass of water on an empty stomach.
Can etoposide be given orally?
Oral etoposide is given by mouth, in the form of a capsule. The capsule(s) should be swallowed whole, on an empty stomach (1 hour before or 2 hours after eating). Do not chew, open, break or crush the capsules. The dosage and schedule are determined by the person’s size, type of cancer, and mode of administration.
What is durvalumab approved for?
The US FDA has granted durvalumab accelerated approval for the treatment of patients with locally advanced or metastatic urothelial carcinoma who have disease progression during or following platinum-containing chemotherapy, or within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy.
What is durvalumab used for?
Durvalumab is used to treat non-small cell lung cancer (NSCLC) that spread to nearby tissues and cannot be removed by surgery but has not worsened after being treated with other chemotherapy medications and radiation treatments.
How is taxol given?
Taxol is given as an injection or infusion into the vein (intravenous, IV). Taxol is an irritant. An irritant is a chemical that can cause inflammation of the vein through which it is given. If the medication escapes from the vein it can cause tissue damage.
Is etoposide FDA approved?
Accordingly, the application is approved. The Division of Bioequivalence has determined your Etoposide Injection USP, 20 mg/mL to be bioequivalent and, therefore, therapeutically equivalent to the listed drug (Vepesid® 20 mg/mL of Bristol Laboratories, Inc.).
Is there a shortage of Etopophos 1 g phosphate?
Consumers and health professionals are advised that information regarding the status of shortages relating to Etopophos etoposide 1 g (as phosphate) and Etopophos etoposide phosphate 113.6 mg (equivalent to 100 mg etoposide) powder for injection vials has changed.
How often should I take Etopophos for lung cancer?
The recommended dose of ETOPOPHOS is: • 50 to 100 mg/m 2 per day administered intravenously over 5 minutes to 3.5 hours on days 1 through 5 of each 21-day (or 28-day cycle), or • 100 mg/m 2 administered intravenously over 5 minutes to 3.5 hours on days 1, 3, and 5 of each 21-day (or 28-day cycle). 2.2 Small Cell Lung Cancer
How is etoposide converted to its active moiety?
Etoposide phosphate is a prodrug that is converted to its active moiety, etoposide, by dephosphorylation. Etoposide causes the induction of DNA strand breaks by an interaction with DNA-topoisomerase II or the formation of free radicals, leading to cell cycle arrest, primarily at the G2 stage of the cell cycle, and cell death. 12.2 Pharmacodynamics
What is the half life of etoposide phosphate?
On intravenous administration, the disposition of etoposide is best described as a biphasic process with a distribution half-life of about 1.5 hours and terminal elimination half-life ranging from 4 to 11 hours. Total body clearance values range from 33 to 48 mL/min or 16 to 36 mL/min/m 2