Can you recover from central Sensitisation?
On a cellular/molecular level, central sensitization may be reversed through degradative glutamate receptor pathways. This, however, rarely happens. Instead, cortical brain regions may serve in a top-down regulatory capacity for the maintenance or alleviation of pain.
Is sensitization reversible?
Central sensitization can be difficult to diagnose, but fortunately, it’s manageable and often reversible.
What is sensitization pain?
Sensitization is a heightened sensitivity to stimuli that may occur normally in the central or peripheral nervous system, but this condition is also present in many chronic pain conditions. In pathological conditions, sensitization may produce pain stimuli even if no harmful events are occurring.
Does B12 help with nerve pain?
One proposed treatment for neuropathic pain is vitamin B12, which is thought to alleviate pain by a number of mechanisms including promoting myelination, increasing nerve regeneration and decreasing ectopic nerve firing.
How do you treat central nervous system pain?
Pain medications often provide some reduction of pain, but not complete relief of pain, for those affected by central pain syndrome. Tricyclic antidepressants such as nortriptyline or anticonvulsants such as neurontin (gabapentin) can be useful. Lowering stress levels appears to reduce pain.
What should you do if you have central sensitization?
In most cases, exercise is the cornerstone of a good treatment program for central sensitization. Depending on the severity of your pain, your doctor may also prescribe medications for short or medium-term pain relief.
Is it possible to reverse central sensitization in chronic pain?
Fortunately, it can also be reversed under the right conditions ( 2, 3, 4 ). In nearly all chronic pain conditions, physicians and scientists consider central sensitization to be a key source of pain.
Is there comorbidity with central sensitization in pain?
The comorbidity of those pain hypersensitivity syndromes that present in the absence of inflammation or a neural lesion, their similar pattern of clinical presentation and response to centrally acting analgesics, may reflect a commonality of central sensitization to their pathophysiology.
Can a spinal cord injury cause central sensitization?
Central sensitization has long been recognized as a possible consequence of stroke and spinal cord injury. However, it has become increasingly clear that it plays a role in many different chronic pain disorders. It can occur with chronic low back pain, 7, 8 chronic neck pain, 9 whiplash injuries,…