What is intestinal Ganglioneuromatosis?
Intestinal ganglioneuromatosis is a rare neoplastic condition characterized by marked proliferation of ganglion cells, Schwann cells, and nerve fibers in the wall of the bowel. This condition may affect any portion of the gastrointestinal tract, but the ileum, colon, and appendix are most frequently involved [1].
Is ganglioneuroma cancer?
Most ganglioneuromas are noncancerous. The expected outcome is usually good. A ganglioneuroma may become cancerous and spread to other areas.
Is ganglioneuroblastoma malignant?
Ganglioneuroblastoma is an intermediate tumor that arises from nerve tissues. An intermediate tumor is one that is between benign (slow-growing and unlikely to spread) and malignant (fast-growing, aggressive, and likely to spread).
Can ganglioneuroma grow back?
Most ganglioneuromas are noncancerous, thus expected outcome is usually good. However, a ganglioneuroma may become cancerous and spread to other areas, or it may regrow after removal.
What is a mucosal neuroma?
A benign tumor of nerve tissue commonly found on the tongue, lips, or in the gastrointestinal tract. Mucosal neuromas are a characteristic feature of multiple endocrine neoplasia type 2B (also known as MEN3), which is a hereditary syndrome associated with the development of medullary thyroid cancer. Enlarge.
Can Ganglioneuroma turn into neuroblastoma?
Despite these facts, an association of ganglioneuroma and neuroblastoma appears to be existing. A metachronous occurence of ganglioneuroma and neuroblastoma is described in literature and the possibility of maturation of a maligant neuroblastoma to a benign ganglioneuroma is strongly suspected [3].
Is a Ganglioneuroma a paraganglioma?
Tumors that arise from chromaffin cells of the adrenal medulla are called pheochromocytomas, whereas those that occur in paraganglia at other sites are referred to as paragangliomas [9]. Ganglioneuroma is a benign neoplasm composed of Schwann cells and ganglion cells.
Are Glioneuronal tumors malignant or benign?
Glioneuronal tumors presenting with epilepsy were observed to have relatively benign biological behavior. The completeness of the tumor resection is of paramount importance in avoiding tumor progression and malignant transformation, which are rare in cases of epileptogenic glioneuronal tumors.
Are mucosal neuromas painful?
Neuromas. Neuromas arise in three settings. Traumatic neuromas are solitary, painful nodules that develop in scars after surgery or trauma. Pain resolves quickly after surgical excision.
What is MEN4?
Multiple endocrine neoplasia type 4 (MEN4) is a rare autosomal dominant endocrine tumor syndrome. The most common tumors seen in this condition involve the parathyroid glands, anterior pituitary, and gastro-entero-pancreatic neuroendocrine tissues.
What kind of polyposis is diffuse intestinal ganglioneuromatosis?
Diffuse intestinal ganglioneuromatosis is a hamartomatous polyposis characterized by a disseminated, intramural or transmural proliferation of neural elements involving the enteric plexuses. It has been associated with MEN II, neurofibromatosis type 1 and hamartomatous polyposis associated with phosphatase and tensin homolog mutation.
What are the symptoms of intestinal ganglioneuromatosis?
INTRODUCTION. Intestinal ganglioneuromatosis is a hamartomatous polyposis usually reported in children and uncommon in adults consisting of hyperplasia of the myenteric plexus and the enteric nerve fibers[ 1 ]. The most common symptoms caused are change in bowel habit and gastrointestinal bleeding.
Is there a proximal resection margin for ganglioneuromatosis?
Ganglioneuromatosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/colontumorganglioneuromatosis.html. Accessed September 18th, 2021. Proximal resection margin unremarkable. Negative for malignancy. Three benign lymph nodes.