Is cilastatin a beta lactamase inhibitor?
Imipenem-cilastatin-relebactam (IMI-REL) is a novel β-lactam-β-lactamase inhibitor combination recently approved for the treatment of complicated urinary tract infections (cUTIs) and complicated intraabdominal infections (cIAIs).
What class is imipenem?
Imipenem, the first of a new class of carbapenem antibiotics, has potent activity against most clinically important species of bacteria, including isolates resistant to other antibiotics.
What is cilastatin mechanism?
Imipenem + cilastatin is a beta-lactam antibiotic of the carbapenems class with a broad spectrum of activity. The mechanism of action is similar to the other beta-lactam antibiotics, which is to inactivate the penicillin-binding proteins (PBP) and cause cell wall lysis, or interfere with cell wall formation.
What is the purpose of cilastatin?
Imipenem and cilastatin is a combination medicine used to treat severe infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs. Imipenem and cilastatin may also be used for purposes not listed in this medication guide.
Why are carbapenems administered with cilastatin?
Carbapenems are eliminated by the kidneys. Imipenem is hydrolyzed by renal tubular dipeptidase. Imipenem is therefore always combined with cilastatin, which inhibits this breakdown. Other carbapenems do not require coadministration with cilastatin because they are not metabolized by dipeptidase.
When do you use Recarbrio?
Recarbrio is a combination medicine that is used to treat complicated infections of the urinary tract (bladder and kidneys) or infections within the stomach area (abdomen). Recarbrio is also used to treat pneumonia (a lung infection) caused by being in a hospital or using a ventilator.
What drug classification is imipenem and cilastatin?
Imipenem is in a class of medications called carbapenem antibiotics. It works by killing bacteria. Cilastatin is in a class of medications called dehydropeptidase inhibitors.
What are the classes of antibiotic?
Classes of antibiotics include the following:
- Aminoglycosides.
- Carbapenems.
- Cephalosporins.
- Fluoroquinolones.
- Glycopeptides and lipoglycopeptides.
- Macrolides.
What type of antibiotic is cilastatin?
Cilastatin is in a class of medications called dehydropeptidase inhibitors. It works by helping imipenem stay active in your body for a longer period of time. Antibiotics such as imipenem and cilastatin injection will not work for colds, flu, or other viral infections.
Why imipenem is administered with cilastatin?
Because imipenem is rapidly inactivated by renal dehydropeptidase I (DHP-1), it is given in combination with cilastatin (sye” la stat’ in), a DHP-I inhibitor which increases half-life and tissue penetration of imipenem.
Is Tobramycin an aminoglycoside?
The aminoglycoside class of antibiotics consists of many different agents. In the United States, gentamicin, tobramycin, amikacin, plazomicin, streptomycin, neomycin, and paromomycin are approved by the US Food and Drug Administration (FDA) and are available for clinical use.
What is Recarbrio?
RECARBRIO is a combination of the previously approved drugs (imipenem/cilastatin and a new drug (relebactam). RECARBRIO should only be used when the infection is caused by bacteria or strongly suspected to be caused by bacteria.
What are the different brand names of cilastatin?
Multi-ingredient medications containing cilastatin: cilastatin/imipenem systemic. Brand names: Primaxin IV, Primaxin IM. Drug class(es): carbapenems. Cilastatin/imipenem systemic is used in the treatment of: Aspiration Pneumonia. Bacteremia.
Why is cilastatin used as an intravenous antibiotic?
8.1 Pharmacology. Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase. Renal Dehydropeptidase degrades the antibiotic imipenem. Cilastatin is therefore combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect.
Where is cilastatin found in the human body?
Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase. Dehydropeptidase is found in the kidney and is responsible for degrading the antibiotic imipenem.
What are the side effects of cilastatin injection?
severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment) Imipenem and cilastatin injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.