What does the MYCN gene do?
The MYCN gene is a member of the Myc family of oncogenes. These genes play important roles in regulating cell growth and division (proliferation) and the self-destruction of cells (apoptosis).
What is the difference between MYC and MYCN?
Expression of MYCN is tissue specific, and is found during early developmental stages, whereas expression of MYC is more generalized (Fig. 1C). For example, expression of MYCN is highest in forebrain, kidney, and hindbrain of newborn mice, and is virtually absent in all tissues of adult mice.
What is MYCN amplification?
A laboratory test in which cells in a sample of tumor tissue or bone marrow are checked to see how many copies of the MYCN gene are in the tumor DNA. MYCN is important for cell growth. Having more than 10 copies of the gene is called MYCN gene amplification.
Which chromosome is MYCN on?
MYCN amplification is also correlates with 1p36 deletion and gain of chromosome 17q. MYCN amplified cell lines also overexpress ID2. There have been a number of reports of MYCN amplification in retinoblastoma cell lines and primary tumours.
What chromosome is N myc?
The N-myc gene, MYCN, is located on the distal short arm of chromosome 2 (2p24). In cells with amplification, the extra copies typically reside as double minute or homogenously staining region amplicons (77). Additional genes may be coamplified with MYCN in a subset of neuroblastomas (DDX1, NAG, and ALK; ref.
Which chromosome is Mycn on?
What does Mycn stand for?
MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian))
| Nomenclature | |
|---|---|
| Atlas | NMYCID112 |
| Entrez_Gene (NCBI) | MYCN MYCN proto-oncogene, bHLH transcription factor |
| Aliases | MODED; N-myc; NMYC; ODED; |
| bHLHe37 |
What viruses are oncogenic?
Oncogenic DNA viruses include EBV, hepatitis B virus (HBV), human papillomavirus (HPV), human herpesvirus-8 (HHV-8), and Merkel cell polyomavirus (MCPyV). Oncogenic RNA viruses include, hepatitis C virus (HCV) and human T-cell lymphotropic virus-1 (HTLV-1).
How does the mutation of Myc alter the cell cycle?
Myc transcription factor leads to upregulation of several genes which are involved in cell cycle progression, apoptosis, and cellular transformation, leading to increased cell number and thus, cancer.
How does MYCN siRNA affect the Wnt pathway?
Treatment with MYCN siRNA or 5-aza-2′-deoxycytidine (5-AdC), a demethylating agent, significantly increased the levels of DKK3 mRNA and protein and decreased the protein levels of p-GSK3β and nuclear β-catenin, which indicates inhibition of the Wnt/β-catenin pathway in vitro.
How does MYCN work in adult B-all that?
MYCN knockdown significantly decreased the tumorigenic capacity of Nalm6 cells, which restored DKK3 levels and inhibited the Wnt/β-catenin pathway in vivo. Our study provides an increased understanding of adult B-ALL pathogenesis, which may be beneficial to the development of effective prognostic markers or therapeutic targets.
How is the MYCN gene related to other genes?
The MYCN protein regulates the activity of other genes by attaching (binding) to specific regions of DNA and controlling the first step of protein production (transcription). On the basis of this action, this protein is called a transcription factor. The MYCN gene belongs to a class of genes known as oncogenes.
How does MYCN affect the treatment of cancer?
It relied on the JNK-IRE1-mTORC1 pathway. The drug vorinostat also reduced cell viability/proliferation in the treated cells and this was dependent on the presence of MYCN as MYCN siRNA transfection led to a blunting of vorinostat efficacy and conversely, MYCN overexpression improved the vorinostat potency in those cells.
https://www.youtube.com/watch?v=BEWjOCVEN7M