What are metabolites of opioids?
Opioids are subject to O-dealkylation, N-dealkylation, ketoreduction, or deacetylation leading to phase-I metabolites. By glucuronidation or sulfatation, phase-II metabolites are formed. Some metabolites of opioids have an activity themselves and contribute to the effects of the parent compound.
What metabolite means?
Listen to pronunciation. (meh-TA-boh-lite) A substance made or used when the body breaks down food, drugs or chemicals, or its own tissue (for example, fat or muscle tissue). This process, called metabolism, makes energy and the materials needed for growth, reproduction, and maintaining health.
Where are narcotics metabolized?
The liver is the major site of biotransformation for most opioids. Thus, the disposition of these drugs may be affected in patients with liver insufficiency. The major metabolic pathway for most opioids is oxidation.
What do metabolites mean?
(meh-TA-boh-lite) A substance made or used when the body breaks down food, drugs or chemicals, or its own tissue (for example, fat or muscle tissue). This process, called metabolism, makes energy and the materials needed for growth, reproduction, and maintaining health. It also helps get rid of toxic substances.
What are examples of metabolites?
Examples of primary metabolites are ethanol, glutamic acid, aspartic acid, 5′ guanylic acid, acetic acid, lactic acid, glycerol, etc. Examples of secondary metabolites are pigments, resins, terpenes, ergot, alkaloids, antibiotics, naphthalenes, nucleosides, quinolones, peptides, growth hormones, etc.
What are bacterial metabolites?
The metabolites identified by the researchers are short chain fatty acids (SCFAs) generated when bacteria in the colon break down fiber in food. There are several kinds of short chain fatty acids. For example, acetic acid is a short chain fatty acid found in vinegar.