Is CD30-positive lymphoproliferative disorder cancer?
Primary cutaneous CD30-positive T-cell lymphoproliferative disorders are the second most common subgroup of cutaneous T-cell lymphomas. They include two clinically different entities with some overlapping features and borderline cases: lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma.
Is lymphomatoid papulosis rare?
Lymphomatoid papulosis is rare, affecting 1.5 people in a million. It most commonly occurs in adults in their 40s but can develop in all age groups. This condition does not run in families and is not contagious. Treatment can decrease the frequency of new bumps, but there is no cure.
How is lymphomatoid papulosis treated?
Low-dose weekly methotrexate (MTX) [35, 36, 37, 38] is a safe and effective treatment for suppressing lymphomatoid papulosis (LyP) [39, 40] ; however, the disease recurs within 1-2 weeks after discontinuing the medication. Oral psoralen plus UVA (PUVA) phototherapy also effectively treats and suppresses the disease.
What is CD30 positive?
CD30-positive cells characterize lymphomatoid papulosis and anaplastic large cell lymphoma but can also be found in nonneoplastic skin disorders. Purportedly, CD30 is useful in the differential diagnosis between insect bites and lymphomatoid papulosis.
What does Papulosis mean?
[pap″u-lo´sis] the presence of multiple papules.
What are CD30 cells?
A protein found on some T cells and B cells (two types of white blood cells). It is a receptor for a protein called tumor necrosis factor, which is involved in cell growth and cell survival.
Is Sezary syndrome hereditary?
In people affected by the condition, the cancerous T- cells (also called Sezary cells) usually have one or more chromosomal abnormalities . These genetic changes are considered “somatic” because they are acquired during a person’s lifetime, are not inherited and only affect the DNA of the cancerous cells.