What is the drug of choice for uncomplicated malaria?
The recommended drugs for uncomplicated malaria are artesunate + amodiaquine (ASAQ) or artemether + lumefantrine (AL).
What is the current best treatment for malaria caused by Plasmodium falciparum?
Artemisinin combination therapy is recommended for the treatment of uncomplicated P. falciparum malaria. Artemether with lumefantrine is the drug of choice; artenimol with piperaquine phosphate is a suitable alternative.
What is the second line treatment of uncomplicated malaria?
In 2007, the Ministry introduced Lumefantrine-Artemether (LA) as the first- line treatment and Artesunate-Amodiaquine (ASAQ) as the second-line treatment for uncomplicated malaria.
What are the classes of antimalarial?
Medication Summary The 4 major drug classes currently used to treat malaria include quinoline-related compounds, antifolates, artemisinin derivatives, and antimicrobials. No single drug that can eradicate all forms of the parasite’s life cycle has been discovered or manufactured yet.
What is the management of uncomplicated malaria?
The first-line recommendations for uncomplicated malaria include artemether-lumefantrine (AL), at a total dose of 5–24 mg/kg body weight (BW) of artemether and 29–144 mg/kg of lumefantrine plus 0.25 mg/kg BW single low-dose (SLD) primaquine, and chloroquine 25 mg/kg BW for the treatment of Plasmodium falciparum and …
What is uncomplicated falciparum malaria?
DEFINITION OF UNCOMPLICATED MALARIA. A patient who presents with symptoms of malaria and a positive parasitological test (microscopy or RDT) but with no features of severe malaria is defined as having uncomplicated malaria (see section 7.1 for definition of severe malaria).
What medication is used to treat malaria?
Malaria is particularly dangerous for children and pregnant women and most malaria deaths occur in small children. Acute malaria is usually treated with Quinine or Chloroquine.
What is artesunate protocol?
Per WHO guidelines, 3 doses of IV artesunate, administered intravenously over 1–2 minutes, at 12-hour intervals (0, 12, and 24 hours) is recommended for treatment of severe malaria. The dosing of IV artesunate is: 2.4 mg/kg at 0, 12, and 24 hours and can be continued daily for up to a total of 7 days, if needed.