How do Adenoviruses infect cells?
Overview of virus entry. Adenovirus entry into cells, as defined by experiments with cultured cells, generally involves attachment to a primary receptor, followed by interaction with a secondary receptor responsible for internalization.
How does adenovirus cause infection?
Adenovirus can spread through droplets when someone with an infection coughs or sneezes. Fecal material (poop) can spread the infection via contaminated water, dirty diapers, and poor hand washing. Outbreaks of pharyngoconjunctival fever at summer camps are linked to contaminated water in swimming pools and lakes.
What type of cells do Adenoviruses infect?
Currently, about 110 human adenovirus (HAdV) types and genotypes are known and classified into seven species (A-G). AdVs infect the respiratory organs, the eyes, the kidney, the gastrointestinal tract and blood cells. On a population scale, AdVs emerge unpredictable, and can cause human epidemics.
What receptor does adenovirus bind to?
Adenoviruses use remarkably diverse attachment receptors, five of which have been studied structurally in the context of HAdV binding: Coxsackie and Adenovirus Receptor, CD46, the glycans GD1a and polysialic acid, and desmoglein-2.
Where do adenoviruses come from?
Adenovirus is often cultured from the pharynx and stool of asymptomatic children, and most adults have measurable titers of anti-adenovirus antibodies, implying prior infection. Adenovirus is known to be oncogenic in rodents but not in humans.
How long does it take to get over adenovirus?
The body’s immune system fights the viral infection and it typically resolves in 5-7 days. Antibiotics do not treat viral infections. Treatment typically consists of supportive care, such as rest, fluids, or over-the-counter fever relievers.
What are the symptoms of adenovirus?
Symptoms
- common cold or flu-like symptoms.
- fever.
- sore throat.
- acute bronchitis (inflammation of the airways of the lungs, sometimes called a “chest cold”)
- pneumonia (infection of the lungs)
- pink eye (conjunctivitis)
What is adenovirus infection?
Adenoviruses are common viruses that cause a range of illness. They can cause cold-like symptoms, fever, sore throat, bronchitis, pneumonia, diarrhea, and pink eye (conjunctivitis). You can get an adenovirus infection at any age.
How many human adenoviruses are there?
In humans, currently there are 88 human adenoviruses (HAdVs) in seven species (Human adenovirus A to G): A: 12, 18, 31. B: 3, 7, 11, 14, 16, 21, 34, 35, 50, 55.