Is carbamazepine a teratogenic?
Therefore, carbamazepine is considered a human teratogen as it leads to major and minor abnormalities in fetuses and babies such as developmental problems, abnormal IQ and growth retardation (32).
Which drug is contraindicated during pregnancy due to its teratogenicity?
Teratogenic drugs and birth defects isotretinoin (an acne drug) alcohol. cocaine. high doses of vitamin A.
What drug affects teratogenicity?
Primidone crosses the human placenta. Potential teratogenic effects include craniofacial anomalies, bleeding, and intrauterine growth retardation. It is categorized by the US Food and Drug Administration and the Australian Drug Evaluation Committee as pregnancy category D.
Which of the following is a teratogenic agent?
A teratogenic agent can be a medicinal product or other chemical agent (i.e., alcohol, nicotine), an infectious agent (i.e., rubella, cytomegalovirus), a medical condition (i.e., diabetes), an environmental toxin or genetic disorder. Teratogens cause about 10% of all birth defects (Box 8.1).
Is there a teratogenic effect of carbamazepine use during pregnancy?
Some epidemiological human studies reported that teratogenic effect of carbamazepine use during pregnancy due to its high level of developmental toxicity. The incidence of congenital anomalies is three times in babies of mothers who use carbamazepine during pregnancy than those in general population (Briggs et al.,2008).
What kind of treatment is methotrexate used for?
Methotrexate has been used for the treatment of malignancy, rheumatic disorders, and psoriasis and termination of intrauterine pregnancy. Recently, methotrexate has become a standard treatment for ectopic pregnancy.
What kind of methotrexate is used for ectopic pregnancy?
Recently, methotrexate has become a standard treatment for ectopic pregnancy. The misdiagnosis of an intrauterine pregnancy as an ectopic pregnancy can result in exposure of a continuing pregnancy to dose levels of methotrexate of 50 mg/m(2) (maternal body surface area).
What happens if a pregnancy is misdiagnosed with methotrexate?
The misdiagnosis of an intrauterine pregnancy as an ectopic pregnancy can result in exposure of a continuing pregnancy to dose levels of methotrexate of 50 mg/m(2) (maternal body surface area). Experimental animal studies have associated methotrexate therapy with embryo death in mice, rats, rabbits, and monkeys.