What is the difference between Daratumumab and Isatuximab?
Additionally, isatuximab inhibits CD38 enzymatic activity more effectively than daratumumab3, resulting in decreased adenosine production, and may alleviate the immunosuppressive microenvironment of the bone marrow niche in MM patients4.
What is refractory myeloma?
Multiple myeloma is a cancer that affects a type of white blood cell called a plasma cell, which helps your immune system fight infections. Refractory means your cancer doesn’t improve with treatment, or it stops responding to treatment. Sometimes the first treatment you try doesn’t work against your cancer.
What is triple class refractory myeloma?
A person’s multiple myeloma is said to be triple-class refractory if it is resistant to all three classes of standard myeloma therapies, which include: Proteasome inhibitors. Immunomodulatory agents. Monoclonal antibodies.
What is Lenalidomide Refractory?
And so, the major definition for being refractory to lenalidomide, Revlimid, is that you must have progressed on full doses of Revlimid or had an inadequate response with full doses, or the maximum doses that could be tolerated for the Revlimid.
Is isatuximab chemo?
Drug Type: Isatuximab is an anti-cancer (“antineoplastic” or “cytotoxic”) drug. This medication is a monoclonal antibody directed against CD38, a molecule present on myeloma cells (for more detail, see “How Isatuximab Works” below).
What is isatuximab used for?
Generic Name: isatuximab-irfc This medication is used to treat a certain type of cancer (multiple myeloma). Isatuximab belongs to a class of drugs known as monoclonal antibodies. It works by slowing or stopping the growth of cancer cells.
What is the lifespan of someone with multiple myeloma?
The SEER(Surveillance, Epidemiology, and End Results) data for multiple myeloma has been published in 2013 by the National Cancer Institute, and the average life expectancy remains at 4 years for the third year in a row. However, some people beat the odds and live 10 to 20 years or more.
How I treat relapsed/refractory myeloma?
Patients who experience a biochemical relapse may be treated by increasing the medication dose if they are on maintenance lenalidomide; reintroducing dexamethasone; and/or adding another agent, such as elotuzumab.
What is triple myeloma?
Multiple myeloma is a cancer that forms in a type of white blood cell called a plasma cell. Healthy plasma cells help you fight infections by making antibodies that recognize and attack germs. In multiple myeloma, cancerous plasma cells accumulate in the bone marrow and crowd out healthy blood cells.
How is first relapse of myeloma treated?
https://www.youtube.com/watch?v=6qbPIWPS8Gk