Can carbamazepine cause thyroid problems?
OBJECTIVES – While carbamazepine (CBZ) decreases thyroid hormone concentrations it rarely causes hypothyroidism.
Does antiepileptic drugs cause hypothyroidism?
Rationale: Antiepileptic drugs (AEDs) are one of the causative drugs of drug-induced hypothyroidism. In most cases, AED-induced hypothyroidism is subclinical and indicated only by abnormalities of free thyroxine (T4) and/or thyroid-stimulating hormone (TSH) levels.
Does Tegretol effect thyroid?
Carbamazepine (applies to Tegretol) thyroid function tests Decreased values for thyroid function tests have been observed with carbamazepine administration. One study reported decreased serum levels of T4, FT4, and T3. In that study, TSH concentrations were not significantly altered.
Can valproic acid cause hypothyroidism?
Valproic Acid Therapy Causes Subclinical Hypothyroidism in Children with Epilepsy.
Can valproate cause hypothyroidism?
Secondary deficiency of zinc and selenium due to valproate may decrease the synthesis of thyroid hormone and cause hypothyroidism with elevated TSH [9, 10]. However, in adults with bipolar disorder, the mechanism of valproate-induced hypothyroidism has been poorly studied.
Is epilepsy related to thyroid?
Thyroid hormones play essential roles in the brain physiological processes. Epilepsy is accompanied with mitochondrial dysfunction and oxidative stress. Mitochondrial dysfunction and oxidative stress are linked with thyroid dysfunction. Inhibitory/excitatory imbalance is common between epilepsy and thyroid dysfunction.
Does sodium valproate cause hypothyroidism?
Can epilepsy medication cause thyroid problems?
Thyroid hormones may fluctuate with exposure to antiepileptic drugs. The use of certain antiepileptic drugs may cause alterations in thyroid hormone levels in patients with epilepsy.
Can taking drugs affect your thyroid?
Drugs and alcohol are essentially poisons that can affect hormone production by damaging the thyroid. Alcohol contains phytoestrogens, and can create an imbalance of estrogen when consumed in excess. Additionally, alcohol can turn androgen and testosterone, the male hormones, into more estrogen.
Does valproate affect thyroid levels?
Conclusions: Valproate monotherapy may cause significant alteration in thyroid profile in children with epilepsy, occurring early in the course of treatment and persisting as long as VPA is initiated.