Can hydrocortisone be given Intrathecally?
Introduction: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.
Which drug should never be given intrathecal?
Accidental administration of any vinca alkaloids—especially vincristine but also vinblastine, vinorelbine, or others—via the intrathecal route is nearly always fatal.
Which group of drugs must never be given by intrathecal administration?
To avoid the accidental administration of vincristine and other vinca alkaloids (Vinblastine, Vindesine, Vinorelbine) by the intrathecal route and in light of the National patient safety agency rapid response report NPSA/2008/RRR004: 1. For adults and adolescents vinca doses in syringes should no longer be used.
What are the different methods to administer the drugs by intrathecal route *?
Intrathecal delivery involves the direct injection of the drug into the CSF within the intrathecal space of the spinal column, whereas drugs injected in the epidural space have to cross the dura membrane in order to reach the CSF.
Why is hydrocortisone given Intrathecally?
Prophylactic intrathecal methotrexate and hydrocortisone reduces central nervous system recurrence and improves survival in aggressive non-hodgkin lymphoma. Cancer.
Why is methotrexate given Intrathecally?
Methotrexate is a chemotherapy drug that is used to treat certain types of cancer and leukaemia. When given intrathecally, it prevents leukaemia cells entering the cerebrospinal fluid (CSF) around the spine and brain. It is also used to treat leukaemia found in the CSF.
Can cytarabine be administered intrathecally?
Cytarabine 100 mg/ml Injection is a ready to use injection and can be administered by the intravenous and subcutaneous routes. Cytarabine 100 mg/ml Injection should not be administered by the intrathecal route due to the slight hypertonicity of this formulation.
Who can prescribe intrathecal drugs?
Prescribing Intrathecal chemotherapy should be approved and prescribed only by Consultant Haematologists, Staff Grade or Associate Specialist Haematologists who are authorised by the Lead Clinician for this specific area of clinical practice (Appendix 1).
Is intrathecal the same as subarachnoid?
The intrathecal space may also be referred to as the subarachnoid space.
What is topical route?
Most often topical administration means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including creams, foams, gels, lotions, and ointments. Many topical medications are epicutaneous, meaning that they are applied directly to the skin.
Can a cytarabine injection be given both intravenously and intrathecal?
When cytarabine injection is administered both intrathecally and intravenously within a few days, there is an increased risk of spinal cord toxicity, however, in serious life-threatening disease, concurrent use of intravenous and intrathecal Cytarabine Injection is left to the discretion of the treating physician.
How often should I take cytarabine for CSF?
CYTARABINE 50 mg INTRATHECAL STAT Then if blast cells are identified in the CSF sample: CYTARABINE 50 mg INTRATHECAL on Day 1, 3, 5 each week until there are two clear CSF samples. Thereafter repeat treatment at approximately 2 weekly intervals until consolidation treatment is completed.
What are the side effects of cytarabine injections?
The main toxic effect of cytarabine injection is bone marrow suppression with leukopenia, thrombocytopenia and anemia. Less serious toxicity includes nausea, vomiting, diarrhea and abdominal pain, oral ulceration, and hepatic dysfunction.
How is cytarabine used in the treatment of cancer?
INDICATIONS AND USAGE Cytarabine Injection in combination with other approved anti-cancer drugs is indicated for remission induction in acute non-lymphocytic leukemia of adults and pediatric patients. It has also been found useful in the treatment of acute lymphocytic leukemia and the blast phase of chronic myelocytic leukemia.