What is sodium succinate used for?
This medication is used to treat conditions such as arthritis, blood disorders, severe allergic reactions, certain cancers, eye conditions, skin/kidney/intestinal/lung diseases, and immune system disorders.
How chloramphenicol succinate is activated?
The palmitate ester is hydrolysed in the small intestine to active chlor- amphenicol prior to absorption. Chloramphenicol succinate acts as a prodrug, being con- verted to active chloramphenicol while it is circulating in the body.
What type of antibiotic is chloramphenicol?
Chloramphenicol is a semisynthetic, broad-spectrum antibiotic derived from Streptomyces venequelae with primarily bacteriostatic activity. Chloramphenicol diffuses through the bacterial cell wall and reversibly binds to the bacterial 50S ribosomal subunit.
What is Solumedrol used to treat?
What are side effects of methylprednisolone?
Methylprednisolone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- upset stomach.
- stomach irritation.
- vomiting.
- headache.
- dizziness.
- insomnia.
- restlessness.
- depression.
What is the effect of chloramphenicol?
The most serious adverse effect of chloramphenicol is bone marrow depression. Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia, and granulocytopenia) are known to occur after the administration of chloramphenicol.
Why is chloramphenicol so effective?
Chloramphenicol is bacteriostatic but may be bactericidal in high concentrations or when used against highly susceptible organisms. Chloramphenicol stops bacterial growth by binding to the bacterial ribosome (blocking peptidyl transferase) and inhibiting protein synthesis.
What is mechanism of action of chloramphenicol?
Chloramphenicol is an antibacterial agent with a broad spectrum of activity against gram-positive bacteria, gram-negative bacteria, and Rickettsia. Its mechanism of action is by inhibition of bacterial protein synthesis by binding with ribosomes.
Is it safe to give chloramphenicol sodium succinate intravenously?
CHLORAMPHENICOL SODIUM SUCCINATE IS INTENDED FOR INTRAVENOUS USE ONLY. IT HAS BEEN DEMONSTRATED TO BE INEFFECTIVE WHEN GIVEN INTRAMUSCULARLY. Chloramphenicol sodium succinate must be hydrolyzed to its microbiologically active form, and there is a lag in achieving adequate blood levels compared with the base given intravenously.
How much sodium is in a gram of chloramphenicol?
Each gram (10 mL of a 10% solution) of chloramphenicol sodium succinate contains approximately 52 mg (2.25 mEq) of sodium. The chemical name for chloramphenicol sodium succinate is D-threo-(-)-2, 2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl] acetamide α-(sodium succinate).
What is the chemical name for sodium succinate?
The chemical name for chloramphenicol sodium succinate (chloramphenicol sodium succinate (chloramphenicol sodium succinate (chloramphenicol sodium succinate injection) injection) injection) is D-threo-(-)-2, 2-Dichloro-N-[β- hydroxy-α-(hydroxymethyl)-p-nitrophenethyl] acetamide α-(sodium succinate).
Which is the chemical formula for Chloramphenicol succinate?
Chloramphenicol succinate. PubChem CID. 656580. Structure. Find Similar Structures. Chemical Safety. Laboratory Chemical Safety Summary (LCSS) Datasheet. Molecular Formula. C15H16Cl2N2O8.