Does isoniazid cause vitamin B6 deficiency?
INH toxicity stems from several causes, including deficiencies of pyridoxine (vitamin B6) and gamma amino butyric acid (GABA). INH induces a state of functional pyridoxine deficiency by at least two mechanisms. First, INH metabolites directly attach to and inactivate pyridoxine species.
What is the most prominent adverse effect of isoniazid?
Common side effects may include: numbness, tingling, or burning pain in your hands or feet; nausea, vomiting, upset stomach; or. abnormal liver function tests.
How does isoniazid affect pyridoxine?
Isoniazid competes for these same enzymes, which reduces the amount of the activated form of pyridoxine in the body. Isoniazid metabolites also react with pyridoxine to deactivate it. Taking isoniazid thus reduces the amount of pyridoxine that the body effectively has, and this deficiency causes neuropathy.
How does isoniazid affect vitamin B6?
Isoniazid can interfere with the activity of vitamin B6. Vitamin B6 supplementation is recommended, especially in people with poor nutritional status, to prevent development of isoniazid-induced peripheral neuritis (inflamed nerves). One case is reported in which injectable vitamin B6 reversed isoniazid-induced coma.
Why Vitamin B6 is combined with isoniazid treatment?
Vitamin B6 (pyridoxine) supplementation during isoniazid (INH) therapy is necessary in some patients to prevent the development of peripheral neuropathy.
What does isoniazid do to the body?
What is isoniazid? Isoniazid is an antibiotic that fights bacteria. Isoniazid is used to treat and to prevent tuberculosis (TB). You may need to take other TB medicines in combination with isoniazid.
Why vitamin B6 is combined with isoniazid treatment?
Why is B6 given in TB?
Vitamin B6 is used to prevent numbing and tingling of the hands or feet sometimes caused by isoniazid or other TB medicines.
How much Vitamin B-6 should you take daily?
The daily recommended intake of vitamin B6 is 1.3 milligrams for adults between the ages of 18 and 50. After age 50, men need 1.7 milligrams a day and women need 1.5 milligrams. According to the…
Are there any risks in taking vitamin B6?
High-dose vitamin B supplements should be avoided, because they can lead to nerve damage. Taking too much vitamin B6 can also cause sensitivity to the sun, painful and disfiguring skin lesions and gastrointestinal symptoms, such as nausea and heartburn. Taking vitamin B6 can also interfere with several types of medications.
What is vitamin B6 used for?
Vitamin B6 is used for preventing and treating low levels of pyridoxine (pyridoxine deficiency) and the anemia that may result. It is also used for heart disease, premenstrual syndrome (PMS), depression, and many other conditions.
Can B6 be toxic?
The current recommended maximum daily intake is 100 mg. High doses of the B6 vitamin can, over time, be toxic, and may result in nerve damage or numbness and tingling in the extremities that may eventually be irreversible.