Which of the following genetic disorders is created by a translocation between chromosome 9 and chromosome 22?
A rearrangement (translocation) of genetic material between chromosomes 9 and 22 causes a type of cancer of blood-forming cells called chronic myeloid leukemia. This slow-growing cancer leads to an overproduction of abnormal white blood cells.
What syndrome is caused by a translocation?
Individuals with Emanuel syndrome inherit an unbalanced translocation between chromosomes 11 and 22 that introduces extra genetic material in the form of the der(22) chromosome. This extra genetic material causes birth defects and the other health problems characteristic of this disorder.
What is the job of chromosome 9?
Chromosome 9 likely contains 800 to 900 genes that provide instructions for making proteins. These proteins perform a variety of different roles in the body.
What is the translocation of chromosomes 9 and 22 known as?
Somatic: BCR-ABL gene fusion The Philadelphia chromosome is a reciprocal translocation involving chromosomes 9 and 22 that is commonly identified in chronic myelogenous leukemia (CML). The break points of the translocation create a fusion of two genes: ABL1 on chromosome 9 and BCR on chromosome 22.
Is chromosome translocation hereditary?
A translocation is either inherited from a parent or happens around the time of conception. A translocation cannot be corrected – it is present for life. A translocation is not something that can be ‘caught’ from other people. Therefore a translocation carrier can still be a blood donor, for example.
How do you know if you have translocation?
Your geneticist will offer to test other members of your family to find out whether your translocation is a new one or a family one. A small blood sample is needed for the test. Testing both your parents may be enough but if that is not possible, other family members may also be invited for testing.
What is a DNA translocation?
​Translocation Translocation is a type of chromosomal abnormality in which a chromosome breaks and a portion of it reattaches to a different chromosome. Chromosomal translocations can be detected by analyzing karyotypes of the affected cells.