Can EBV cause T cell lymphoma?
EBV has been linked to several malignancies, including nasopharyngeal carcinoma, gastric carcinoma and lymphomas/lymphoproliferative diseases including Burkitt lymphoma, classical Hodgkin lymphoma, post-transplantation lymphoproliferative disorders, NK/T cell lymphoma (nasal type), aggressive NK-cell leukemia.
Does Epstein Barr virus cause Burkitt’s lymphoma?
EBV is a member of the herpesvirus family that has been strongly implicated in the endemic form of Burkitt lymphoma (eBL). Virtually all patients with eBL are EBV positive, whereas only about 20% of sporadic (sBL) cases are associated with EBV.
Does EBV infect T cells?
EBV is able to infect T cells in vivo, as evidenced by its association with a variety of T-cell lymphoproliferative disorders; however the role EBV plays in the pathogenesis of these diseases is currently unknown.
What are EBV T cells?
T-cell chronic active Epstein-Barr virus (CAEBV) is a rare disease in which EBV is present predominantly in T cells that infiltrate the tissues; patients have high levels of EBV in the blood.
What is Hydroa Vacciniforme?
Hydroa vacciniforme (HV) is a rare, chronic photodermatosis of unknown origin occurring in childhood that exists within the spectrum of Epstein-Barr virus–related lymphoproliferative disorders. These range from classic HV to fatal lymphoma.
What is Angioimmunoblastic lymphoma?
AITL is a type of peripheral T-cell lymphoma. It is a high grade (aggressive) lymphoma that affects blood cells called T cells. High grade lymphomas tend to grow more quickly than low grade lymphomas. AITL usually affects older people, typically around the age of 70.
How does EBV cause non-Hodgkin’s lymphoma?
EBV’s Connection to NHL People age 65 years and older who had EBV at one time are at a higher risk for developing B-cell NHL because of the way the immune system ages over time. An EBV infection reprograms or hijacks B cells to become cancerous.
Why does EBV cause Burkitt’s lymphoma?
Subsequently, studies have shown that EBV has the ability to immortalize B-lymphocytes by hindering apoptosis signals within the cell. The virally encoded cells, therefore, proliferate to high numbers in the body leading to malignancies. EBV can subsequently change the B-lymphocytes to lymphoblastoid cell lines.
Where is Burkitt lymphoma found?
Endemic Burkitt lymphoma originates in Africa. It is the most common type of Burkitt lymphoma and the most common childhood cancer overall. It has an incidence rate of about 50 times higher in equatorial Africa and New Guinea than in the U.S. The most common site of endemic disease is the jaw.
What is an EBV T-cell?
What cell type does EBV infect?
Human B cells are the primary targets of Epstein Barr virus (EBV) infection. In most cases EBV infection is asymptomatic because of a highly effective host immune response but some individuals develop self-limiting infectious mononucleosis, while others develop EBV-associated lymphoid or epithelial malignancies.