What drug is a mineralocorticoid receptor antagonist?
The two commonly used mineralocorticoid receptor antagonists are spironolactone and eplerenone, although these agents are currently not approved by the US Food and Drug Administration for use in ESKD. Spironolactone is more potent, whereas eplerenone is more specific for the mineralocorticoid receptor.
How does Finerenone cause less hyperkalemia?
Finerenone is evenly distributed in the heart and kidneys, whereas eplerenone is at least 3 times higher in the kidneys than in the heart. This might be the reason why finerenone has a cardiac effect at a relatively low dose and the incidence of hyperkalemia induced by finerenone is lower than that of spironolactone.
Which is a aldosterone blocking agent?
Aldosterone antagonists are diuretics or “water pills.” They may also be called aldosterone receptor blockers. Aldosterone antagonists include: Eplerenone (Inspra) Spirinolactone (Aldactone)
What are aldosterone receptor blockers?
Aldosterone receptor antagonists (also called an antimineralocorticoid, MCRA, and sometimes MRA) are a class of drugs which block the effects of aldosterone. Aldosterone is the main mineralocorticoid hormone in the body and is produced in the adrenal cortex of the adrenal gland.
What do mineralocorticoid receptor antagonists do?
Aldosterone antagonists (antimineralocorticoid or mineralocorticoid receptor antagonists) are diuretics or “water pills” used for the treatment of high blood pressure or heart failure. They work by inhibiting the effects of aldosterone, a mineralocorticoid hormone secreted by the adrenal gland.
What is a mineralocorticoid receptor blockers?
Mineralocorticoid receptor antagonists are diuretic drugs that work primarily on the kidneys. They decrease sodium reabsorption which leads to increased water excretion by the kidneys.
Does finerenone lower blood pressure?
Finerenone is a non-steroidal mineralocorticoid receptor blocker, which means its chemistry is very different, pharmacokinetics are very different, and frankly, its clinical properties and effects are very different. Finerenone does not lower blood pressure, not significantly, 1 millimeter.
Is finerenone an aldosterone antagonist?
Finerenone is a third-generation nonsteroidal mineralocorticoid receptor antagonist with stronger mineralocorticoid receptor-binding potential compared with spironolactone and eplerenone.
What is a mineralocorticoid receptor blocker?
What happens when mineralocorticoid receptors are blocked?
Specifically, mineralocorticoid receptor blockade decreased glomerular hypertrophy, mesangial matrix expansion, glomerular inflammation, and interstitial inflammation.
What are the side effects of mineralocorticoid?
Most adverse reactions are caused by the drug’s mineralocorticoid activity (retention of sodium and water) and include hypertension, edema, cardiac enlargement, congestive heart failure, potassium loss, and hypokalemic alkalosis.
When do you use Finerenone?
Finerenone has been used in Phase III clinical trials for the treatment of patients with diabetic kidney disease and for reducing the risk of cardiovascular events in patients with diabetic kidney disease.