Does danazol cause weight gain?
Danazol is an effective treatment for endometriosis, and has the same effectiveness as the other hormonal treatments. However, it has many androgenic (male-like) side effects, including weight gain, increased body hair and acne.
Does danazol cause hair loss?
Mild hirsutism, edema, hair loss, voice change, which may take the form of hoarseness, sore throat or of instability or deepening of pitch, may occur and may persist after cessation of therapy.
When should I take danazol?
You should start taking danazol on the first day of your next period unless you have been told otherwise. Your doctor will tell you how many capsules to take each day, and when you should take them. As a guide, for the treatment of endometriosis or breast pain, danazol is usually taken 2-4 times daily for 3-6 months.
Why has danazol been discontinued?
The other manufacturer, Mylan, have identified a problem with the active pharmaceutical ingredient (API) which has led to the discontinuation of danazol capsules within the UK and supplies of both strengths are now exhausted.
Who should not take danazol?
Danazol must not be taken by women who are pregnant or who could become pregnant. Danazol may harm the fetus. You will need to have a negative pregnancy test before you begin taking this medication. Start taking this medication during your menstrual cycle to be sure you are not pregnant.
Does hair grow back after medication?
In most cases, hair will grow back by itself once a person stops taking the medication. People may be able to help hair growth with at-home treatments. If people are seeing no signs of regrowth after 6 months, they can discuss other treatment options with their doctor.
Can danazol cause blood clots?
Danazol can increase your risk that you will develop a blood clot in your arms, legs, lungs, heart, and brain that may cause a heart attack or stroke. Tell your doctor if you have or ever had a blood clot.
What happens when you stop taking danazol?
Using danazol may cause irregular monthly periods or absence of menstrual period. If your regular monthly period does not begin within 60 to 90 days after you stop taking danazol, check with your doctor right away.
Is danazol still available?
DANOCRINE (danazol) Capsules, 50 mg, 100 mg, and 200 mg, were discontinued from sale in December 2004. FDA moved the product to the “Discontinued Drug Product List” section of the Orange Book at that time.
Has danazol been discontinued?
Danazol 100mg and 200mg capsules have been discontinued in the UK and remaining supplies of both strengths are now exhausted. Danazol has several licensed indications and off-label uses. The management of patients prescribed danazol for licensed indications will differ to those prescribed danazol for an off-label use.
How should I take danazol?
Before you start the treatment,read the manufacturer’s printed information leaflet from inside the pack.
Is Danazol an anabolic steroid medication?
Danazol has a complex mechanism of action, and is characterized as a weak androgen and anabolic steroid, a weak progestogen, a weak antigonadotropin, a weak steroidogenesis inhibitor, and a functional antiestrogen. Danazol was discovered in 1963 and was introduced for medical use in 1971.
What is the rationale for using danazol for endometriosis?
Danazol can help treat endometriosis by stopping the growth and function of that endometrial tissue. It has this effect because it blocks the production of certain hormones that cause menstruation and growth of endometrial tissue.
Can danazol cause breast pain?
Danazol, tamoxifen, and gonadorelin analogues (goserelin) may reduce breast pain, but all can cause adverse effects. These agents would usually be prescribed only by a subspecialist. Danazol can cause weight gain, deepening of the voice, menorrhagia, and muscle cramps, and has androgenic effects on a fetus.