What does ROR gamma t do?
Retinoid-related orphan receptor gamma t (RORgamma t) is a member of the nuclear receptor family that is specifically expressed in T cell compartments. RORgamma t regulates the development of T cells in the thymus and the differentiation of effector T cells in the periphery.
Do humans have the RORB gene?
RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the RORB gene.
What is Rora disease?
RORA (RAR Related Orphan Receptor A) is a Protein Coding gene. Diseases associated with RORA include Intellectual Developmental Disorder With Or Without Epilepsy Or Cerebellar Ataxia and Epidermolysis Bullosa Acquisita.
What is rorb protein?
RORB (RAR Related Orphan Receptor B) is a Protein Coding gene. Diseases associated with RORB include Epilepsy, Idiopathic Generalized 15 and Epilepsy, Idiopathic Generalized. Among its related pathways are Circadian rythm related genes and Gene Expression. An important paralog of this gene is RORA.
What is il17a?
Interleukin-17 (IL-17, also known as IL-17A) is a key cytokine that links T cell activation to neutrophil mobilization and activation. As such, IL-17 can mediate protective innate immunity to pathogens or contribute to the pathogenesis of inflammatory diseases, such as psoriasis and rheumatoid arthritis.
What is Rorb Modelling?
RORB is a general runoff and streamflow routing program used to calculate flood hydrographs from rainfall and other channel inputs. In addition to normal channel storage, specific modeling can be provided for retarding basins, storage reservoirs, lakes or large flood plain storages.
What is the function of the RORB gene?
| Molecular function | Activator, Developmental protein, DNA-binding, Receptor |
|---|---|
| Biological process | Biological rhythms, Sensory transduction, Transcription, Transcription regulation, Vision |
| Ligand | Metal-binding, Zinc |
What does Rev Erb stand for?
Abstract. The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are involved in many physiological processes, including regulation of metabolism, development and immunity as well as the circadian rhythm.
What is the function of Rorb protein?
Are Th17 cells tregs?
As two important subsets of T helper cells, Th17 and Treg represent two arms of an immune response. Th17 cells can participate in the defense against extracellular bacterial and fungal infections. On the other hand, Treg cells can regulate the immune response and maintain immune homeostasis.
What does T helper 17 do?
T helper 17 (Th17) cells, characterized by secretion of IL-17 and IL-17F, are a specialized CD4+ effector T cell lineage that not only facilitates host defense against pathogen infection and maintenance of mucosal barrier, but also potently induces tissue inflammation and autoimmune diseases.