What is the function of Dysbindin?
Dysbindin is involved in intracellular protein trafficking involving lysosomes and related organelles and it is important for synaptic homeostasis (1, 9).
What is dysbindin 1?
Dysbindin-1 is a protein encoded by dystrobrevin-binding protein 1 gene (DTNBP1), which is located on the short (p) arm of chromosome 6 at position 22.3 [30]. Initially, dysbindin-1 was found to be a component of the dystrophin-associated protein complex (DPC) in skeletal muscle cells.
Can schizophrenia be genetic?
Genetics. Schizophrenia tends to run in families, but no single gene is thought to be responsible. It’s more likely that different combinations of genes make people more vulnerable to the condition. However, having these genes does not necessarily mean you’ll develop schizophrenia.
What are the 3 phases of schizophrenia?
Schizophrenia consists of three stages: prodromal, active, and residual.
When was dysbindin first identified as a risk for schizophrenia?
Dysbindin, encoded by the DTNBP1 (dystrobrevin binding protein) gene, was first identified as a schizophrenia risk allele in a study of 270 Irish families in 2002 (Straub et al., 2002).
Where is the dysbindin gene located on the chromosome?
DTNBP1 Gene The dystrobrevin-binding protein 1 gene (DTNBP1) is localized on chromosome 6p22.3. This protein, also known as dysbindin, has a strong association with schizophrenia by single nucleotide polymorphism (SNP) and haplotype association studies.
Where are dysbindin-1 mRNA levels found in schizophrenia?
In particular, studies have reported consistently that schizophrenia patients have lower expression levels of dysbindin-1 mRNA and protein in the prefrontal cortex (PFC) and hippocampus ( Talbot et al., 2004; Tang et al., 2009a; Weickert et al., 2004, 2008 ).
What is the role of dysbindin-1 in the synaptic?
Indeed, dysbindin-1 has been indicated to play a crucial role in synaptic homeostasis and efficacy.