What does low WBC and high monocytes mean?
Monocytes and other kinds of white blood cells are necessary to help the body fight disease and infection. Low levels can result from certain medical treatments or bone marrow problems, while high levels can indicate the presence of chronic infections or an autoimmune disease.
What causes low white blood cells in horses?
A decrease in the total numbers of white blood cells (leukopaenia) may be due to overwhelming bacterial or viral infection, bone marrow disease or endotoxaemia. Neutrophils – These are the most common white blood cells in the horse. They move rapidly to sites of infection or inflammation within the body.
What is the most common cause of leukopenia?
Blood cell and bone marrow conditions: These can lead to leukopenia. Examples include aplastic anemia, overactive spleen, and myelodysplastic syndromes. Cancer: Leukemia and other cancers may damage the bone marrow and lead to leukopenia. Infectious diseases: Examples include HIV, AIDS, and tuberculosis.
What are two causes of leukopenia?
Leukopenia
- Aplastic anemia – A condition where the bone marrow doesn’t produce new blood cells.
- Autoimmune disorders – Conditions that attack the white blood cells or bone marrow cells, such as lupus or rheumatoid arthritis.
- Cancer or diseases of the bone marrow – Such as multiple myeloma.
What does Monocytosis indicate?
When your monocyte level is high — known as monocytosis — it means your body is fighting something. Some conditions that can cause an increase in the monocytes in your blood are: viral infections, such as infectious mononucleosis, mumps, and measles. parasitic infections. chronic inflammatory disease.
What is Monocytosis?
Monocytosis is defined as a monocyte count that exceeds the upper limit of the reference range of 0.95 X 199/L (950/μL). Monocytosis is commonly caused by the following conditions: Bacterial infections: These include tuberculosis, subacute bacterial endocarditis, and brucellosis.
What causes liver problems in horses?
Liver disease in mature horses is most often caused by exposure to toxic plants or feed toxins, infection, or bile stones. Horses can occasionally develop serious liver disease after treatment with products produced from horse blood, such as plasma or tetanus antitoxin.
Can horses get Ehrlichia?
Equine ehrlichiosis is a seasonal disease of horses first reported in 1969. Clinical signs in horses include high fever, depression, partial hypophagia, anorexia, limb edema, petechiation, icterus, ataxia, and reluctance to move.
What is Monocytosis when does it occur?
Monocytosis is defined by an absolute monocyte count of greater than 500/µL and usually occurs in the setting of chronic inflammation resulting from infections like tuberculosis, syphilis, or subacute bacterial endocarditis, autoimmune or granulomatous disease, and sarcoidosis.
What does leukopenia indicate?
Definition. By Mayo Clinic Staff. A low white blood cell count (leukopenia) is a decrease in disease-fighting cells (leukocytes) in your blood. Leukopenia is almost always related to a decrease in a certain type of white blood cell (neutrophil).
What is the most common cause of monocytosis?
Common infections causing monocytosis include tuberculosis, subacute bacterial endocarditis, syphilis, protozoal or rickettsial disease. Common autoimmune diseases in the differential include SLE, rheumatoid arthritis, sarcoidosis, and inflammatory bowel disease.
What causes decrease in white blood cells in horses?
Leukopenia in horses occurs in equine herpesvirus infections, equine ehrlichiosis, influenza, and sometimes during the early stages of equine infectious anemia. In addition to an overall increase or decrease in white blood cells, increases or decreases in each type of white blood cell can lead to—and help diagnose—-disorders.
Can a stress leukogram increase neutrophil count in horses?
In general, it would be uncommon for a stress leukogram to increase a segmented neutrophil count >10-12,000/μL in horses and ruminants.
How to diagnose monocytosis plus dysplasia?
Monocytosis plus dysplasia or additional complete blood count abnormalities such as anemia, thrombocytopenia, eosinophilia, or basophilia, or clinical indicators of malignancy such as splenomegaly, bone pain, or weight loss among others indicate a clonal etiology and in these cases a bone marrow aspirate/core biopsy assessment should be performed.
What causes a person to go into monocytosis?
Transient causes:Monocytosis can been seen in a patient with recovering bone marrow after cytotoxic chemotherapy. Stressful events such as splenectomy, myocardial infarction, and exercise can also result in monocytosis and are often transient and reversible [7•].