What is trimethoprim used to treat?
Trimethoprim is an antibiotic. It’s used to treat and prevent urinary tract infections (UTIs), such as cystitis. Occasionally, trimethoprim is used to treat other types of infections, such as chest infections and acne. Trimethoprim is available on prescription.
Why is trimethoprim used as a antibiotic?
Trimethoprim is an antibiotic used to treat bacterial infections. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu).
Which bacteria does trimethoprim treat?
Although rarely used alone because of bacterial resistance, trimethoprim may be used to treat uncomplicated urinary tract infections caused by Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species, and coagulase-negative Staphylococcus.
What is trimethoprim made from?
Trimethoprim (trimethoprim) Tablets USP, 100 mg contain the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, magnesium stearate, sodium lauryl sulfate, sodium starch glycolate and stearic acid.
Is trimethoprim good for UTI?
Trimethoprim is an antibiotic that is used to treat bladder or kidney infections, or ear infections caused by certain bacteria.
Is trimethoprim used alone?
Trimethoprim can be used alone or, less commonly, is combined with the sulfonamide sulfamethoxazole as co-trimoxazole.
What is trimethoprim in English?
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. Other uses include for middle ear infections and travelers’ diarrhea. With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS. It is taken by mouth.
What is the brand name for trimethoprim?
Trimethoprim is available under the following different brand names: Primsol, Proloprim, and TMP.
What is the mechanism of action of trimethoprim?
Mechanism of action Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.
Can trimethoprim affect kidneys?
Our results show that trimethoprim is associated with greater risk of acute kidney injury and hyperkalaemia compared with other antibiotic drugs for a UTI, among the general population aged 65 and over, and not just those treated with renin-angiotensin system blockers.
What kind of infections can trimethoprim be used for?
Trimethoprim ( TMP) is an antibiotic used mainly in the treatment of bladder infections. Other uses include for middle ear infections and travelers’ diarrhea. With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS.
When was trimethoprim first used in the United States?
Trimethoprim. Trimethoprim was first used in 1962. It is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system. It is available as a generic medication and is not very expensive. In the United States, ten days of treatment costs about $21.
What are the names of sulfamethoxazole and trimethoprim?
Trimethoprim/sulfamethoxazole may be abbreviated as SXT, TMP-SMX, TMP-SMZ, or TMP-sulfa. Co-trimoxazole ( BAN) is manufactured and sold by many different companies. The following list of brand names is incomplete: Trimethoprim/sulfamethoxazole is relatively inexpensive as of 2019.
Are there any birth defects associated with trimethoprim?
Based on the studies that show that trimethoprim crosses the placenta and can affect folate metabolism, there has been growing evidence of the risk of structural birth defects associated with trimethoprim, especially during the first trimester of pregnancy.