What drug class is Namenda?
NAMENDA is a prescription medicine used for the treatment of moderate to severe dementia in people with Alzheimer’s disease. NAMENDA belongs to a class of medicines called NMDA (N-methyl-Daspartate) inhibitors. It is not known if NAMENDA is safe and effective in children.
What is the purpose of memantine?
Memantine reduces the actions of chemicals in the brain that may contribute to the symptoms of Alzheimer’s disease. Donepezil and memantine is a combination medicine used to treat moderate to severe dementia of the Alzheimer’s type.
What drug class is memantine?
Memantine is in a class of medications called NMDA receptor antagonists. It works by decreasing abnormal activity in the brain. Memantine may improve the ability to think and remember or may slow the loss of these abilities in people who have AD.
What is the difference between donepezil and memantine?
Donepezil showed an advantage over memantine in mild-to-moderate AD, whereas memantine was more effective than donepezil in severe AD. The combination therapy of memantine plus donepezil achieved better outcomes than placebo in the CGI.
Can memantine cause heart failure?
In particular, there is evidence of increased risk of syncope, bradycardia, QT interval prolongation, ventricular tachycardia, and atrioventricular block with AChEIs. 2, 3, 4, 5, 6, 7, 8 Moreover, memantine has been associated with an increased risk of myocardial infarction,9 among other cardiovascular events.
What class of drug is memantine?
How is Memantine used in the treatment of dementia?
Memantine is an oral N-methyl-D-aspartate glutamate receptor antagonist used in the therapy of Alzheimer disease and dementia. Memantine is associated with a minimal rate of serum enzyme elevations during therapy and has only rarely been implicated as a cause of clinically apparent acute liver injury.
What should I tell my doctor about memantine?
To make sure memantine is safe for you, tell your doctor if you have: epilepsy or other seizure disorder; liver disease; kidney disease; urination problems; or a bladder or kidney infection.
Are there any pharmacokinetic interactions with memantine?
Studies have shown that memantine produces minimal inhibition of CYP450 enzymes CYP1A2, CYP2A6, CYP2C9, CYP2D6, CYP2E1, and CYP3A4, indicating that no pharmacokinetic interactions with drugs metabolized by these enzymes are expected.
Can a cholinesterase inhibitor be added to memantine?
A more recent systemic review and meta-analysis indicates that memantine is beneficial as a first line drug for the treatment of Alzheimer’s dementia. Cholinesterase inhibitors may be added to memantine for further beneficial effects on behavioral symptoms and other symptoms of dementia.