Is subacute sclerosing panencephalitis a latent viral infection?
Subacute sclerosing panencephalitis (SSPE) is a rare, predominantly childhood-onset neurologic illness that probably results from a latent or mutant measles (rubella) virus infection of neurons. Alternatively, the body’s aberrant response to this infection causes the illness.
What is subacute sclerosing panencephalitis SSPE )? Symptoms causes?
Subacute Sclerosing Panencephalitis (SSPE)
- Subacute sclerosing panencephalitis is caused by the measles virus.
- The first symptoms are usually poor school performance, forgetfulness, temper outbursts, distractibility, sleeplessness, and hallucinations.
- The diagnosis is based on symptoms.
- This disorder is usually fatal.
Can you survive SSPE?
No cure for SSPE exists, and the condition is almost always fatal. SSPE should not be confused with acute disseminated encephalomyelitis, which can also be caused by the measles virus, but has a very different timing and course. SSPE is caused by the wild-type virus, not by vaccine strains.
Which infection has a complication of SSPE?
Subacute sclerosing panencephalitis (SSPE) is a progressive, disabling, and deadly brain disorder related to measles (rubeola) infection. The disease develops many years after the measles infection.
What causes subacute sclerosing panencephalitis?
Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder characterized by inflammation of the brain (encephalitis). The disease may develop due to reactivation of the measles virus or an inappropriate immune response to the measles virus.
How do you treat SSPE?
Treatment for SSPE is still undetermined. A combination of oral isoprinosine (Inosiplex) and intraventricular interferon alfa appears to be the best effective treatment. Patients responding to treatment need to receive it life long.
How does measles cause subacute sclerosing panencephalitis?
Measles virus may cause immediate symptoms of brain infection (encephalitis. The spinal cord may also be involved… read more ), or the virus may remain in the brain for a long time without causing problems. Subacute sclerosing panencephalitis occurs because the measles virus reactivates.
What does subacute sclerosing panencephalitis mean?
Definition. Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder of children and young adults that affects the central nervous system (CNS). It is a slow, but persistent, viral infection caused by defective measles virus.
What is the meaning of Panencephalitis?
[ păn′ĕn-sĕf′ə-lī′tĭs ] n. Encephalitis that affects both the gray and white matter of the brain, resulting in progressive loss of mental and motor functions.
What are the symptoms of neurosyphilis?
Symptoms
- Abnormal walk (gait), or unable to walk.
- Numbness in the toes, feet, or legs.
- Problems with thinking, such as confusion or poor concentration.
- Mental problems, such as depression or irritability.
- Headache, seizures, or stiff neck.
- Loss of bladder control (incontinence)
- Tremors, or weakness.
What virus causes measles?
Measles is caused by a single-stranded, enveloped RNA virus with 1 serotype. It is classified as a member of the genus Morbillivirus in the Paramyxoviridae family. Humans are the only natural hosts of measles virus.
What are the symptoms of subacute sclerosing panencephalitis?
[2] [4] Subacute sclerosing panencephalitis (SSPE) generally develops approximately seven to ten years after a person recovers from the measles. Early signs and symptoms of the condition can include behavioral changes and mild mental deterioration (affecting memory, thinking, language, and judgment).
What is the cause of Progressive rubella panencephalitis?
Progressive rubella panencephalitis is a rare slowly progressive neurological disorder that closely resembles subacute sclerosing panencephalitis. It is caused by the rubella virus and develops because of congenital rubella syndrome or childhood rubella infection (German measles).
What are the signs and symptoms of SSPE?
After asking about your medical history, your doctor will check for the following signs of SSPE: damage to your optic nerve. damage to the retinas in your eyes. muscle twitching. poor performance on movement and coordination tests.