What is the CCR2 gene?
CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Human Immunodeficiency Virus Type 1 and Idiopathic Anterior Uveitis. Among its related pathways are A-beta Uptake and Degradation and Defensins.
Is CCL2 a gene?
CCL2 (C-C Motif Chemokine Ligand 2) is a Protein Coding gene. Diseases associated with CCL2 include Neural Tube Defects and Human Immunodeficiency Virus Type 1. Among its related pathways are p70S6K Signaling and A-beta Uptake and Degradation.
What does CXCL12 stand for?
C-X-C motif chemokine ligand 12
Stromal cell-derived factor 1
| CXCL12 | |
|---|---|
| Aliases | CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, C-X-C motif chemokine ligand 12 |
| External IDs | OMIM: 600835 MGI: 103556 HomoloGene: 128606 GeneCards: CXCL12 |
| showGene location (Human) | |
| showGene location (Mouse) |
What does CCL2 stand for?
Introduction. Monocyte chemoattractant protein-1 [MCP-1, chemokine nomenclature: C–C motif chemokine ligand 2 (CCL2)] is a member of the chemokine family, a collection of small, secreted, chemotactic cytokines, named after their best known function of attracting cells (1).
What cell types express CCR2?
CCR2 was highly expressed by inflammatory monocytes, dendritic cells, plasmacytoid dendritic cells and NK cells in all tissues. Unexpectedly, more than 60% of neutrophils expressed CCR2, albeit at low levels. CCR2 expression in T cells, B cells and NK T cells was greatest in the BM compared to other tissues.
Where is CCR2?
This CCR2 gene is located in the chemokine receptor gene cluster region.
What induces CCL2?
CCL2 is induced by RANKL in mononuclear precursor cells,311 and enhances the ability of RANKL to stimulate osteoclast-like cell formation in these cells. Treatment of monocytes with CCL2 alone induced the production of multinucleated- and calcitonin receptor-positive cells.
Where is CCL2 from?
CCL2 is primarily secreted by monocytes, macrophages and dendritic cells. Platelet derived growth factor is a major inducer of CCL2 gene. CCR2 and CCR4 are two cell surface receptors that bind CCL2. CCL2 exhibits a chemotactic activity for monocytes and basophils.
Where is CXCR4?
CXCR4 is a G-protein-coupled seven transmembrane receptor that was originally cloned as an orphan chemokine receptor and was known as LESTR or fusin. CXCR4 is expressed on the cell surface of most leukocytes, including all B cells, and monocytes and most T lymphocyte subsets, but just weakly on NK cells.
Where is CCL2 produced?
CCL2 is anchored in the plasma membrane of endothelial cells by glycosaminoglycan side chains of proteoglycans. CCL2 is primarily secreted by monocytes, macrophages and dendritic cells. Platelet derived growth factor is a major inducer of CCL2 gene. CCR2 and CCR4 are two cell surface receptors that bind CCL2.
What is CCR2 a marker for?
CCR2 Regulates the Immune Response by Modulating the Interconversion and Function of Effector and Regulatory T Cells.
Where is the CCL12 gene located on the chromosome?
It is thought to coordinate cell movements during early allergic reactions, and immune response to pathogens. The gene for CCL12 is found in a cluster of CC chemokines on mouse chromosome 11. ^ a bJia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J (1996).
What kind of cytokine is CCL12 in mice?
Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CC chemokine family that has been described in mice. It is also known as monocyte chemotactic protein 5 (MCP-5) and, due to its similarity with the human chemokine MCP-1, sometimes it is called MCP-1-related chemokine.
What is the role of CCL12 in fibroproliferation?
Thus, CCL12 is likely the CCR2 ligand responsible for driving fibroproliferation in the mouse. As murine CCL12 is homologous to human CCL2, we suggest that the pathobiology of murine CCL12 in fibroproliferation may correlate to human CCL2 biology.
How are fibrocytes recruited in CCL2-/-mice?
CCL2-/- mice are able to recruit fibrocytes to FITC-injured airspaces, unlike CCR2-/- mice. Adoptive transfer of CCR2-expressing fibrocytes augments FITC-induced fibrosis in both wild-type and CCR2-/- mice, suggesting that these cells play a pathogenic role in the disease process. Both CCL2 and CCL12 are chemotactic for fibrocytes.