What is a pharmaceutical analog?
Analog or analogue drugs are drugs which are “substantially similar” to controlled substances listed in federal or state drug schedules. When drugs are chemically manufactured or synthetic, the drugs may be made with slightly different formulas.
What is drug design and development?
Drug design is the inventive process of finding new medications based on the knowledge of a biological target. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the molecular target with which they interact and bind.
What are the types of drug design?
Drug Design can be categorized as two types: Structure based drug design (SBDD) and Ligand based drug design (LBDD).
Why are analogs important?
Why do we use Analog Missions? Analog missions prepare us for near-term and future exploration to asteroids, Mars, and the Moon. Analogs play a significant role in problem solving for spaceflight research. Not all experiments can be done in space – there is not enough time, money, equipment, and manpower.
What is the difference of digital and analog?
Analog and digital signals are the types of signals carrying information. The major difference between both signals is that the analog signals have continuous electrical signals, while digital signals have non-continuous electrical signals.
What are food analogs designed for?
Food analogs: A manufactured food product designed to imitate a given food and frequently possessing characteristics equal or superior to that food.
What is an analog environment?
Analogue sites are places on Earth with assumed, past or present, geological, environmental or biological conditions of a celestial body. Analogue sites are also important for optimizing scientific and technological needs and exploration strategies in robotic or manned missions to the Moon or Mars.
Which is a special case of analog-based drug design?
Analog-based drug design: A special case of ligand-based drug design wherein the parent ligand is a successfully marketed drug: Ligand-based drug design: At least one, weakly binding ligand for the target is known and it serves as a molecular template for the design of further compounds or exploration of related structural space
What does drug design, discovery and development mean?
1. Drug Design, Discovery and Development Drug design, sometimes referred to as rational drug design or more simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target.
How many drug analogs are there in the world?
Of the 19 analog classes presented in detail, 9 are described by the scientists who discoverd them. The book includes a table of the most successful drug analogs as based on the IMS ranking and compares them in terms of chemical structure, mode of action and patentability.
How are CYPs used in the design of drug analogs?
Microbial CYPs have a potential application in the design of fluorinated drug analogs, whereby incubation of the nonfluorinated drug with a microbial model of mammalian drug metabolism, such as C. elegans or S. griseus, will identify the metabolically labile sites.