What is the difference between myotonic dystrophy 1 and 2?
Myotonic dystrophy type 1 is caused by mutations in the DMPK gene, while type 2 results from mutations in the CNBP gene. The protein produced from the DMPK gene likely plays a role in communication within cells.
Does exercise help Myotonic Dystrophy?
Studies show that moderate exercise is safe and may be effective for individuals with myotonic dystrophy. 1-4 Even though exercise does not cure myotonic dystrophy, it can help optimize function and maintain strength.
Are you born with Myotonic Dystrophy?
Congenital myotonic dystrophy is the early childhood form of myotonic dystrophy (also known as Steinert’s disease). Usually in myotonic dystrophy the symptoms begin to show in childhood or later in life, but symptoms of congenital myotonic dystrophy are evident from birth.
Why does myotonic dystrophy worsen with each generation?
DM1 also exhibits a genetic inheritance pattern called anticipation. This means that the symptoms of the condition worsen and may appear earlier as the mutation is passed on from generation to generation. The type of mutation that causes myotonic dystrophy is called a nucleotide repeat expansion.
Can girls get myotonic dystrophy?
Men and women are equally likely to pass on Myotonic Dystrophy to their children. Myotonic Dystrophy is a genetic disease and so can be inherited by the child of an affected parent if they receive the mutation in the DNA from the parent. The disease can be passed on and inherited equally by both sexes.
How is DM2 similar to myotonic dystrophy type 1?
DM2 is a similar disease to DM1 in that it affects many organs including muscle and is caused by a similar genetic problem but affects a different gene. Even though less is known about DM2 than DM1, DM2 shares enough similarities in its clinical and molecular features that similar principles of management can be applied.
What kind of test is used to diagnose myotonic dystrophy?
There are several laboratory tests that can be used to clarify the clinical diagnosis of myotonic dystrophy. One test, called electromyography (EMG), involves inserting a small needle into the muscle. The electrical activity of the muscle is studied and usually shows characteristic patterns of muscle electrical discharge. [2]
Which is milder, DM1 or DM2?
DM2 is generally a milder condition than DM1.The clinical onset of DM2 is typically in the third or fourth decade, with the most commonly presented symptoms being muscle weakness, stiffness and pain.
What kind of medications can I take for myotonic dystrophy?
Other medications that have been used with some success include gabapentin, nonsteroidal anti-inflammatory drugs (NSAIDS), low-dose thyroid replacement, low-dose steroids, and tricyclic antidepressants. Cholesterol-lowering medications should be avoided when they are associated with increased weakness.