What is half-life of amiodarone?
After long-term oral therapy, amiodarone has a true elimination half-life between 60 and 142 days [2,3].
How long does amiodarone stay in system?
This medication must be taken regularly for one to three weeks before a response is seen and for several months before the full effect occurs. Due to the drug’s long half-life, it will remain in your body for up to two months.
What is amiodarone pharmacokinetics?
Available evidence suggests that absorption of amiodarone following oral administra- tion is erratic and unpredictable; oral bioavailability ranges from 22 to 86%. The drug is eliminated largely by metabolism; less than 1% of the dose is excreted unchanged in the urine.
Why is amiodarone half-life important?
Persistence of Adverse Effects Because of the long half-life of Amiodarone (15 to 142 days) and its active metabolite desethylAmiodarone (14 to 75 days), adverse reactions and drug interactions can persist for several weeks following Amiodarone discontinuation [see Clinical Pharmacology (12.3)].
What is half-life of a drug?
The half-life of a drug is the time it takes for the amount of a drug’s active substance in your body to reduce by half. This depends on how the body processes and gets rid of the drug. It can vary from a few hours to a few days, or sometimes weeks.
What rhythms do you use amiodarone?
This medication is used to treat certain types of serious (possibly fatal) irregular heartbeat (such as persistent ventricular fibrillation/tachycardia). It is used to restore normal heart rhythm and maintain a regular, steady heartbeat.
What class antiarrhythmic is amiodarone?
Although amiodarone is considered a class III anti-arrhythmic agent, it also has class I, II, IV actions, making it a unique and effective anti-arrhythmic agent.
Does amiodarone have a long half-life?
Following single dose administration in 12 healthy subjects, Cordarone exhibited multi- compartmental pharmacokinetics with a mean apparent plasma terminal elimination half-life of 58 days (range 15 to 142 days) for amiodarone and 36 days (range 14 to 75 days) for the active metabolite (DEA).
Why does amiodarone have a long and variable half-life?
The terminal half-life (t1/2 beta) is both long and variable (9-77 days) secondary to the slow mobilization of the lipophilic medication out of (primarily) adipocytes. A pharmacokinetically based loading scheme is described, and data suggesting a role for routine amiodarone plasma levels are presented.
What are the indications for amiodarone?
Dosage Guidelines for Amiodarone (Cordarone)
| Indication | Administration route and setting |
|---|---|
| Life-threatening arrhythmia | IV, inpatient treatment |
| Ventricular arrhythmia | Oral, inpatient treatment |
| Atrial fibrillation | Oral, inpatient or outpatient treatment |
What drugs have long half life?
Drugs that have a long half-life include. Xanax (alprazolam): A longer-acting benzodiazepine, Xanax has a plasma-elimination half-life of around 11 hours. Librium (chlordiazepoxide) is an even longer-acting benzodiazepine drug.
What do you mean by the half life of a drug?
The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. Half-life is used to estimate how long it takes for a drug to be removed from your body.
Is amiodarone safe for arrhythmia?
Amiodarone should only be used if you have a life-threatening arrhythmia or irregular heart rate. This medication has the risk of serious side effects. These include serious lung problems, liver problems, worsening of your irregular heart rate, and loss of vision.
What is the definition of half life of drugs?
The half-life of a drug is an estimate of the period of time that it takes for the concentration or amount in the body of that drug to be reduced by exactly one half (50%). The symbol for half-life is T½.