What is osteosarcoma PDF?
Osteosarcoma is a malignant tumor that primarily affects the long bones but can also involve other bones in the body. It has a bimodal distribution with peaks in the second decade of life and late adulthood.
How many types of osteosarcoma are there?
There are 2 types of osteosarcoma. Each type of osteosarcoma has different subtypes. The type and subtype of osteosarcoma is determined by looking at the tumor cells through a microscope.
What is the main cause of osteosarcoma?
Most osteosarcomas are not caused by inherited gene mutations, but instead are the result of gene changes acquired during the person’s lifetime. Sometimes these gene changes are caused by radiation therapy used to treat another form of cancer, because radiation can damage the DNA inside cells.
What is osteosarcoma Pubmed?
Osteosarcoma is a rare bone tumor found in areas of rapid bone turnover, most commonly the distal femur and proximal tibia of adolescent patients. Early on, treatment of osteosarcoma typically involved surgical resection in the form of amputation or reconstruction with auto- or allograft.
Can osteosarcoma be cured without surgery?
Surgery is an integral part of treatment for patients with localized osteosarcoma as well as select patients with metastatic or recurrent osteosarcoma. Treatment of osteosarcoma without surgery results in significantly lower cure, tumor-free survival, and overall survival rates.
Can osteosarcoma be seen on xray?
Bone x-ray Doctors can often recognize a bone tumor such as an osteosarcoma based on plain x-rays of the bone. But other imaging tests might be needed as well.
What is the difference between sarcoma and osteosarcoma?
Sarcomas are cancers that start in bone, muscle, connective tissue, blood vessels or fat, and can be found anywhere in the body. Types of primary bone cancers include: Osteosarcoma, also known as osteogenic sarcoma, is the most common type of bone cancer and typically starts in bone cells in the arms, legs or pelvis.
Who is at risk for osteosarcoma?
The risk of osteosarcoma is highest for those between the ages of 10 and 30, especially during the teenage growth spurt. This suggests there may be a link between rapid bone growth and risk of tumor formation. The risk goes down in middle age, but rises again in older adults (usually over the age of 60).
What is osteosarcoma article?
Osteosarcoma is a malignant osseous neoplasm. It is the most common primary bone cancer of childhood. Less frequently, it occurs in adults where it represents secondary malignant degeneration of primary bone pathology.
What is secondary osteosarcoma?
Secondary osteosarcomas are osteosarcomas growing on abnormal bone in the setting of various underlying osseous disorders.
Can you be cured of osteosarcoma?
Today, about 3 out of 4 people who have osteosarcoma can be cured if the cancer hasn’t spread to other parts of the body. Almost everyone who is treated with limb-sparing surgery ends up with that arm or leg working well. Many people who have osteosarcoma will need physical therapy for several months after surgery.
What are the first signs of osteosarcoma, symptoms?
Signs and symptoms of osteosarcoma may include, among others: Swelling near a bone Bone or joint pain Bone injury or bone break for no clear reason
Where does bone cancer begin?
Bone cancer can begin in any bone in the body, but it most commonly affects the pelvis or the long bones in the arms and legs.
Where does bone cancer start, osteosarcoma?
For example, the most common type of bone cancer is osteosarcoma, which forms in the bone cells, most often in patients between the ages of 10 and 30. In children, the tumor often begins in spots where the bone is growing quickly, like the upper shin bone, lower thigh bone or the upper arm bone.
What is osteogenic sarcoma?
Osteogenic sarcoma or osteosarcoma is the most frequently occurring type of bone malignancies. It commonly occurs in rapidly growing bones such as the bones of the upper arms, legs, thighs, and the shin. Although its exact cause is unknown, the absence of a tumor-suppressing gene is associated with a higher risk for the development of osteosarcoma.