What is the result of CREB phosphorylation?
Collectively, CREB phosphorylation in T cells is mediated by triggering PKA and PKC, resulting in activation of MAPKs ERK1/2 and p38 and subsequent MSK1/2-mediated CREB phosphorylation that promotes T cell activation and proliferation.
What does phosphorylation of CREB do?
The phosphorylated CREB recognizes the cAMP Response Element and serves as a transcription factor for Per1 and Per2, two genes that regulate the mammalian circadian clock.
Is CREB activated by phosphorylation?
The cAMP-responsive element binding protein (CREB), a key regulator of gene expression, is activated by phosphorylation on Ser-133. Several different protein kinases possess the capability of driving this phosphorylation, making it a point of potential convergence for multiple intracellular signaling cascades.
What is CREB protein mention their significance?
Cyclic AMP Response Element Binding (CREB) protein is a member of the CREB/ATF (Activating Transcription Factor) family of transcription factors playing an important role in the nuclear responses to a variety of external signals that lead to proliferation, differentiation, apoptosis and survival.
What type of protein is CREB?
The CREB promoters from mouse and human cells (121, 122) have been characterized. Both contain an array of Spl and CRE sites (Fig. 10). Transcription of the CREB gene is stimulated by cAMP, and the CRE sites bind CREB, suggesting that the CREB gene is autoregulated.
What happens when CREB transcription factor is phosphorylated?
The CREB is one of the major regulators of neurotrophin responses since phosphorylated CREB binds to a specific sequence in the promoter of BDNF and regulates its transcription. Moreover, susceptibility genes associated with schizophrenia also target and stimulate the activity of CREB.
How does CREB affect memory?
CREB’s affects memory consolidation through its regulation of adult hippocampal neurogenesis (AHN), which mainly occurs in the hippocampal subgranular zone (SGZ) of the dentate gyrus (DG). This mechanism provides a novel perspective on memory consolidation within the adult hippocampus.
What does CREB 2 do?
CAMP response element-binding protein 2(CREB2) is also known as Activating Transcription Factor 2 (ATF2). CREB2 is a CREB repressor, which means it inhibits long-term memory formation. CAMP response element-binding (CREB) proteins are transcription factors which bind to sequences of DNA called cAMP response elements.
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