What is Modomics?
MODOMICS is a database of RNA modifications that provides comprehensive information concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways, the location of modified residues in RNA sequences, and RNA modifying enzymes.
Is Modomics a secondary database?
MODOMICS is the first comprehensive database system for biology of RNA modification.
What information does the Modomics database give you is it a primary secondary or specialized sequence?
At the level of individual protein entries, the database provides information about protein name(s), synonyms, amino acid sequence, corresponding ORF, modified RNA(s) and the position of the residues modified (if available).
What are primary and secondary databases?
Primary databases store and make data available to the public, acting as repositories. Secondary databases make use of publicly available sequence data in primary databases to to provide layers of information to DNA or protein sequence data.
Can RNA be modified?
RNA modifications are changes to the chemical composition of ribonucleic acid (RNA) molecules post-synthesis that have the potential to alter function or stability. An example of RNA modification is the addition of a methylated guanine nucleotide “cap” to the 5′-end of messenger RNAs (mRNAs).
What is database and its types in bioinformatics?
Biological databases can be broadly classified into sequence, structure and functional databases. Nucleic acid and protein sequences are stored in sequence databases and structure databases store solved structures of RNA and proteins. Model Organism Databases are functional databases that provide species-specific data.
What is derived database in bioinformatics?
A database derived from other resources but including relationships or data not found in those resources.
What are the different types of bioinformatics database?
Types of biological database.
Which is secondary database?
Secondary databases contain information derived from primary sequence data which are in the form of regular expressions (patterns), Fingerprints, profiles blocks or Hidden Markov Models. The type of information stored in each of the secondary databases is different.
Which is the example of secondary database?
Secondary databases
| Primary database | |
|---|---|
| Source of data | Direct submission of experimentally-derived data from researchers |
| Examples | ENA, GenBank and DDBJ (nucleotide sequence) ArrayExpress and GEO (functional genomics data) Protein Data Bank (PDB; coordinates of three-dimensional macromolecular structures) |
What happens when you modify RNA?
One of the major impacts of RNA editing is protein recoding. Recoding is the process in which one or more nucleotide changes in RNA results in a different codon. This produces proteins that are different from their genetic forms and these different forms of proteins often have a modified function or structure.